Protein modeling and Rational Drug Designing

Protein modelling and rational drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships automated docking not virtuals screening

Above all, the development of drugs and the evolving medical technologies have become possible when there is a series of experimentation being carried out on animals, specifically for regulated lab research.

Course Goal

The course focuses upon:

• Basic understanding of ligand-protein interactions
• User internet-based structural bioinformatics tools to analyse three-dimensional structures of a protein and a protein-ligand complexes and perform homology-based modeling
• Understand the general principles behind protein crystallization and X-ray crystallography assess the requirements and take active part in the planning and the subsequent development of this type of projects.
• Be familiar with a range of ligand and structure based computational methods
• Perform simple computational modeling tasks using state of the art software.